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I think you would be safe using the higher resolutions but it really depends on your niche. For example a proxy that is going to be used on most schools' out-dated equipment I would make it smaller as the screens are likely 800x600. That is what most of the monitors are at my school. Also just to be safe, always put important navigation and advertisements on the left. If someone with a small screen views your large site, they may not even see the third column so put trivial, not very important things over there.
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