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I manage my domains through a control panel. I personally use WHM which has an excellent interface for managing multiple sites.
Backups - I recommend getting a second hard drive on your server OR manually downloading to your own computer at intervals (every other day, or every week, etc)
I do have a different control panel login for each site though. This allows me to manage the traffic stats, emails, ftp controls, (basically everything) for each site individually.
-matthew
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