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In my memory, it's a real pain.
Last time I had to do so on a 1.5 Go file, I've created an PHP script to do it for me, reading the file line after line, and creating a new file with just the modified lines.
Otherwise, try to use an Hex editor.
As far as I know, the load only a small part of the file in memory.
But, the cannot expand a file, ie: you can only replace characters, not add them.
Or, the last solution, and maybe the easiest:
Import your sql file in a temporary database, make the modifications you need on the datas, and dump the temporary database again.
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