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It is good practice to use relative sizing so user-agents can influence the way the page looks. The ability to resize fonts is crucial for the visiually impaired.
However, if you don't want IE to be able to alter font size use absolute sizing. For example, instead of a font size expressed in a relative way, such as percentage, specify, for example, 18pt. There are 72pts (points), to an inch so this is being specific and giving you more control over the size. Other absolute units include in(inches), mm, pc (picas) and cm.
Bear in mind that some browsers allow a visitor StyleSheet to be applied to a Web page and this will override your own designer choices where there are conflicting formatting instructions.
HTH
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